Abstract:Quantitative analysis of 14 phenolic acids and 12 flavonoids in ethanol extract（EE），petroleum ether fraction（PEF），chloroform fraction（CF），ethyl acetate fraction（EAF），and n-butanol fraction（NF）from Hericium erinaceus was carried out by ultra performance liquid chromatography-electro spray ionization-mass spectrometry.The flavonoid content was much lower than that of phenolic acids.The phenolic acid composition of EE and its four organic extracts were consistent，but the component proportions were significantly different.With flavonoids，composition and content were both significantly different among the five extracts.Among the 26 phenolic compounds，benzoic acid and L-phenylalanine were highest in EE，PEF，CF，and NF，while trans-ferulic acid and epicatechin were highest in EAF.These results can provide a theoretical basis for further development and utilization of Hericium erinaceus phenolic compounds.