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投稿时间：2020-11-25
投稿时间：2020-11-25
中文摘要: 该文建立一种测定纸质食品接触材料中双酚A和双酚S含量的高效液相色谱（high performance liquid chromatography，HPLC）法。方法分析采用 Thermal Ultimate 3000SD 液相色谱仪，ZORBAX Eclipse XDB-CN（250 mm×4.6 mm，5 μm）反相柱。流动相为甲醇/水（体积比 1∶1），等度洗脱，流速 0.8 mL/min；二极管阵列（diode array detector，DAD）检测器，检测波长280 nm和259 nm。结果表明，在1 mg/L～50 mg/L浓度范围内，双酚A和双酚S的浓度与峰面积呈现良好的线性关系，相应的线性相关系数均≥0.999 8，双酚A和双酚S的检出限和定量限分别为0.10、0.02 mg/L和0.50、0.10 mg/L。方法验证过程中做了低、中、高3个水平的添加回收，平均回收率为85.2%～103.0%，相对标准偏差（relative standard deviation，RSD）均小于 5%。
Abstract:A sensitive and rapid method was developed for detection of bisphenol A （BPA）and bisphenol S（BPS）in food packaging papers using high performance liquid chromatography （HPLC）.The procedure was performed with a Thermal Ultimate 3000SD equipped with a ZORBAX Eclipse XDB-CN reversed-phase column（250 mm × 4.6 mm，5 μm）using a methanol and water（volume ratio1∶1）isocratic elution.BPA and BPS were detected with a diode array detector（DAD）set at 280 nm and 259 nm.Flow rate was 0.8 mL/min.BPA and BPS were detected with good linearity within the concentration range of 1 mg/L-50 mg/L.The corresponding linear correlation coefficients were all equal to or greater than 0.999 8.Limits of detection（LOD）and limits of quantification and（LOQ）for BPA and BPS were 0.10 mg/L and 0.02 mg/L，and 0.50 mg/L and 0.10 mg/L respectively.Recovery experiments were carried out at 3 levels using low，medium，and high concentrations.Average recoveries were 85.2%-103.0% and relative standard deviations（RSD）were all below 5%.
keywords: food packaging papers bisphenol A bisphenol S high performance liquid chromatography（HPLC） isocratic elution
文章编号：202117022 中图分类号： 文献标志码：
基金项目:国家重点研发计划（2019YFC0810902、2018YFC0809104、2018YFC0809101）；天津海关科研项目（2020THK011）
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