Abstract:Oral tablets were prepared using a persimmon leaf flavone extract as the primary source material.A preparation process was developed，tablet formulation optimized，and product quality analyzed.Tablet formula optimization was based on an orthogonal experiment，using which，the following optimized formula was obtained:20% persimmon leaf flavone extract，6% β -cyclodextrin，20% mannitol，3% citric acid，7% cross-linked polyvinylpyrrolidone，and 1% magnesium stearate，with starch used as a filler.The prepared tablets were uniform in color，had a good shape，and were acceptable with respect to taste and flavor.Differences in terms of tablet weight，hardness，crispness，and disintegration time were in line with the regulations of the Chinese pharmacopoeia，and the content of flavonoids was 3.13%.