Abstract:The purpose of this experiment was to investigate the effect of millet wine on the activity of antioxidant enzymes in the serum of mice.Specific pathogen-free and healthy Kunming mice were selected for adaptive breeding prior to random allocation in six groups:blank group（0.2 mL saline），wine-based control group（0.2 mL 16.2% ethanol in saline），positive control group（0.2 mL millet juice），low-dose group（0.2 mL millet wine），medium-dose group（0.4 mL millet wine），and high-dose group（0.8 mL millet wine）.The treatments were delivered via oral gavage daily for 30 d.Then，the activities of reduced glutathione（GSH）content and superoxide dismutase（SOD）activity were measured and the change in the level of malon dialdehyde（MDA）content was determined.Compared with that in the alcohol-based group，serum GSH content and SOD activity in the lowdose group were significantly increased（p＜0.05），and MDA content were significantly reduced.These findings indicate that，compared with alcohol at the same concentration，millet wine can reduce liver damage caused by oxidative stress.