Abstract:The reparative effects of flavonoid extracts from black chokeberry on acute alcoholic liver injury in Kunming mice were studied.Flavonoids were extracted from black chokeberry and fed to groups of alcoholic liver injury induced Kunming mice at high or low doses，with the normal group as blank and the model group as control.After five weeks of feeding，aspertate aminotransferase（AST），alanine aminotransferase（ALT），and glutathione peroxidase（GSH-Px）activity，and malondialdehyde（MDA）content and total antioxidant capacity（T-AOC）were assessed in serum and liver tissue from all mice.AST and ALT activity，GSH-Px activity，MDA content，and T-AOC activity in liver and serum of the injury model group were increased compared with that of the uninjured control group.Liver and serum AST and ALT activities were decreased，GSH-Px activity was increased，MDA content was decreased，and T-AOC was increased in the low-dose group relative to the injury model group.Compared with the uninjured control group，liver and serum AST activity were decreased，GSHPx activity was increased，MDA content was decreased，and T-AOC was increased.Compared to the high dose group，liver and serum AST and ALT activities were decreased，MDA content was decreased，and T-AOC was increased.Flavonoid extract from black chokeberry displayed a potent preventive effect on acute alcoholic liver injury in mice，with the more pronounced effect occurring in the low-dose group.