Abstract:The stimulatory effect of Antarctic krill oil on cellular antioxidant capacity in D-galactose-induced aging mice was evaluated in the present study. Male ICR mice were injected subcutaneously with D-galactose（500 mg/kg bw）to establish the aging model. The normal group was injected with an equal volume of normal saline.Six weeks post injection，the aging model mice were divided into a vehicle treated group，and three groups each receiving a different dose of Antarctic krill oil （50，150 and 300 mg/kg bw）.Mice were sorted into groups in a way that equilibrated initial serum malondialdehyde（MDA）distributions between groups.The groups receiving different doses of Antarctic krill oil received their daily doses of krill oil by oral gavage. The healthy group and the vehicle-treated aging model group were given equal volumes of soybean oil by oral gavage.After 30 days of continuous administration，MDA levels，superoxide dismutase（SOD）activities，and protein carbonyl levels in serum，and reduced glutathione（GSH）levels in whole blood were determined. Compared with the healthy group，serum MDA and protein carbonyl levels in the vehicle-treated aging model group were significantly increased（P＜0.05），while serum SOD activities and whole blood GSH levels were significantly decreased（P＜0.01）.Relative to the model group，intervention with Antarctic krill oil increased serum SOD activities and whole blood GSH levels，and reduced serum MDA and protein carbonyl levels in aging model mice.The protective effects seen in the medium and high dose groups were significant （P<0.05）. Antarctic krill oil could efficiently ameliorate oxidative damage caused by D-galactose，and improve cellular antioxidant capacities in aging mice.