Abstract:The effect of ginsenoside Rg1 on immunosuppressive mice with exercise fatigue was studied.Forty male BALB/c mice were randomly divided into blank resting group （NCS），blank exercise group（NCE），immunosuppression model group（MR），ginsenoside Rg1 low-dose group（L，12.5 mg/kg），high-dose group（H，25 mg/kg）.Except for the blank group，mice were injected intraperitoneally with cyclophosphamide，which caused intragastric administration of different doses of ginsenoside Rg1 after the immunocompromised model.After exercising fatigue caused by swimming training，the changes in the weight，organ coefficient and rod climbing time of mice，as well as the changes of blood urea nitrogen （BUN），malondialdehyde（MDA），muscle/hepatic glycogen in serum and skeletal muscle were observed.The results showed that the ginsenoside Rg1 high-dose group increased the rod climbing time by 38.6% and 84.1% compared with the blank exercise group and the model group；high-dose ginsenoside Rg1 could significantly reduce the BUN content and MDA content in liver and skeletal muscle of mice.It could be seen that ginsenoside Rg1 could significantly improve the endurance of experimental mice and regulate the levels of fatigue-related biochemical indicators in serum，liver and skeletal muscle，and had a better anti-exercise fatigue effect for immunosuppressed mice.