Abstract:The effect of instant matured（twin-screw extrusion）GBR on hyperlipidemia model SD rats was investigated.Hyperlipidemia rats were randomly divided into 5 groups：high fat diet group（HFD），high，medium and low-dose group，drug group [HFL：HFD+lipitor，10 mg/（kg·d）]，and set up a normal diet group（ND）.After 7 weeks of intervention，blood samples were taken from the abdominal aorta for biochemical determination.Dose groups compared with HFD，the organ ratio of liver decreased to different extent.The low dose group catalase was significantly lower than HFD by 0.58 （P＜0.05），with no significant difference in drug group.The serum total cholesterol（TC），triglyceride（TG）and low density lipoprotein cholesterol（LDL-C）level of the rats in the dose groups were significantly lower than HFD （P＜0.05），with no significant difference in drug group. It was found that the matured GBR powder had a certain hypolipidemic effect on the SD rats of the hyperlipidemic model. Meanwhile，matured GBR powder could significantly enhance SOD activity. The superoxide dismutase（SOD）concentration in the low dose group catalase was increased by 23.72 U/mL compared to the HFD（P ＜0.05），thus enhance the body's ability to scavenge free radicals，significantly enhance catalase（CAT）activity （P＜0.05）and SOD synergistic action to scavenge oxygen free radicals，at the same time enhance the body's glutathione peroxidase（GSH-Px）activity，reduce the damage of peroxidation to the body.