Abstract:Taken light-damaged mice as model，the water-extracted alcohol precipitation extract of Radix Rehmanniae Preparata and water extract of Radix Rehmanniae Preparata were used to intervene in model mice，respectively，to explore the mitigating effect of Radix Rehmanniae Preparata on visual fatigue.Mice were divided into normal control group，model group，water-extracted alcohol precipitation extract low-dose group（360 mg/kg），high-dose group （450 mg/kg），and water extract group （690 mg/kg），each group were intervened for 8 weeks，and then irradiated with light intensity of（9 000 ± 500）Lux for irradiation（7 d）.After irradiation，the lens and liver were collected to test the antioxidant capacity of the lens and liver.The results showed that by comparing the indexes of glutathione peroxidase（GSH-Px）and total antioxidant capacity（TAOC）in the lens，it was found that the activity of GSH-Px and T-AOC in the model group were significantly lower than that in the normal control group.The GSH-Px and T-AOC activities of the extract group were significantly higher than the model group（P＜0.05），and showed a dose-dependent.From the results of liver antioxidant indexes，compared with the model group，all extract groups could significantly reduce the MDA content and increase the activity of SOD，CAT，GSH-Px，the difference was statistically significant（P＜0.05）.The research results showed that the extract of Radix Rehmanniae Preparata had a good protective effect on the lens of light-damaged mice，and it could relieve visual fatigue.