Abstract:The Shigella is a kind of gram-negative food-borne pathogenic bacteria with strong infectivity and serious harm.In this study，self made CdTe quantum dots were electrostatic coupled with mouse anti-Salmonella monoclonal antibody.Anti-Salmonella monoclonal antibody and sheep anti-mouse antibody were marked on the membrane as test line and control line，separately.A quantum dot immunofluorescence strip was developed for the visual detection of Shigella.the fluorescent immunostrip exhibited a good sensitivity with a limit of detection of 1×104CFU/mL.The detection time of the proposed fluorescent immunostrip for each sample was only 15 min.The fluorescent immunostrip was used to detect five common foodborne pathogens，and the results showed that there were no cross-reactions.The prepared fluorescent immunostrip could provide a visual and highly accurate method for the detection of Shigella in meat.