Abstract:To investigate the protective effects of polysaccharides from auricularia auricula polysaccharide（AAP），polysaccharides from tremella fuciformis polysaccharide（TFP）and hawthorn flavonoids（HF）on blood lipid metabolism and liver in hyperlipidemic mice.90 male Wistar rats were randomly divided into 10 groups：normal control group，model group，positive control groupⅠ （simvastatin），positive control group Ⅱ（fenonote），AAP，TFP，HF，low dose combination（LDC），medium dose combination（MDC），high dose combination（HDC）.The normal control group was fed with basic diet，and the other groups were fed with high fat diet.After 5 weeks of continuous feeding，the body weight gain，feed intake，fat coefficient，organ coefficient，serum total cholesterol（TC），triglyceride（TG），low density lipoprotein cholesterin（LDL-C），high density liptein cholesterol（HDL-C），alanine transaminase（ALT），aspartate amino transferase（AST），and Liver，brain tissue and serum malonaldehyde（MDA），superoxide dismutase（SOD），catalase（CAT），glutathione peroxidase（GSH-Px）were detected，and morphological changes in liver of rat were observed.The results showed that the middle and high dose compound group could reduce the liver coefficient，spleen coefficient and fat coefficient，as well as serum total cholesterol（TC），triglyceride（TG）and low density lipoprotein cholesterol（LDL-C），while the level of high density lipoprotein cholesterol（HDL-C）increased in different degrees.The levels of ALT，AST，malondialdehyde（MDA）and atherosclerotic index（AI）were also effectively reduced.In addition，glutathione peroxidase（GSH-Px）in liver and brain and superoxide dismutase（SOD）and catalase（CAT）in serum increased at different levels.Finally，due to the synergistic effect of their effective substances，the compound of Tremella polysaccharides and Hawthorn flavonoids showed better hypolipidemic and hepatoprotective effects.