Abstract:To investigate the effect of recombinant konjac rice containing konjac glucomannan（KGM）on glycolipid metabolism in type 2 diabetic rats.A rat model of type 2 diabetes was established by feeding high fat purified feed combined with intraperitoneal injection of streptozotocin（STZ）.Model rats were randomly divided into normal control group，model control group，natural rice intervention group，low，medium and high dose group of konjac recombinant rice（KGM content in recombinant rice was 5%，10%，15%，respectively）.After 30 days of dietary intervention，the weight，fasting blood glucose（FBG），oral glucose tolerance（OGTT），glycated hemoglobin（GHb），triglyceride（TG），total cholesterol（TC），high density lipoprotein（HDL-C），low density lipoprotein（LDL-C）and serum insulin（INS）levels of rats were measured.The results showed that natural rice could only significantly reduce the levels of INS，TG and TC in type 2 diabetic rats（P<0.05）.In contrast，recombinant konjac rice could not only to prevent the loss of body weight of type 2 diabetic rats（P<0.05），but also significantly reduce their FBG （P<0.01）and OGTT （P<0.01），as well as decrease the levels of INS，TG，TC and LDL-C，and increase the content of GHb and HDL-C in their serum.It was concluded that replacing natural rice with Konjac recombinant rice could effectively improve the metabolism of glucose and lipid in type 2 diabetic rats and showed good hypoglycemic function.