Abstract:In order to prepare the effervescent tablets of Cordyceps militaris extract，the sensory evaluation，the time limit of disintegration and the hardness were used as indicators.The orthogonal test was used to optimize the addition amount of Cordyceps militaris extract，acid-base ratio of effervescent disintegrant，the total amount of effervescent disintegrants，and the addition amount of sweetener.The effervescent tablet of Cordyceps militaris extract was prepared by the method of non-aqueous granulation after acid-base mixing，and its quality was analyzed.The results of orthogonal test showed that the optimum proportion of the raw and auxiliary materials for the preparation of effervescent tablets was as follows：Cordyceps militaris extract 11%，the ratio of citric acid to sodium bicarbonate 1.3 ∶1（mass ratio），the total mass of effervescent disintegrants 50%and the sweetener aspartame 0.25%.The effervescent tablets prepared according to the best process had smooth and complete appearance，uniform size and color，clear，transparent and acid solution，sweet and sour taste，and special fragrance of Cordyceps militaris.The average hardness was more than 50 N，the foaming amount was 23.95 mL/g，the weight difference and disintegration time met the requirements of 2015 edition of Chinese Pharmacopoeia.The content of Cordyceps polysaccharides was 10.01 mg/g，and the content of cordycepin was 0.65 mg/g.