Abstract:In order to screen out the suitable extraction method of polyphenols from mango kernel，the effect of ultrasonic-assisted extraction and thermal-reflux extraction on the extraction yield of polyphenols were investigated，and the technological parameters of each methods were optimized by response surface methodology on the basis of single factor experiment，respectively.In addition，the antioxidant activities of the crude polyphenols obtained by two methods were evaluated by scavenging DPPH·，ABTS+·，superoxide anion（O2-·）and hydroxyl redicals（·OH）.The more polyphenols were obtained when the ultrasonic-assisted extraction was employed.When the ratio of 60%ethano to dried mango kernel was 38 ∶1 （mL/g），extracted with ultrasound at 79 ℃ and 200 W for 30 min，the extraction yield of polyphenols reached 11.62%.The antioxidant experiments showed that the scavenging capabilities against DPPH·，ABTS +·，O2-· and·OH of the polyphenols via ultrasonic -assisted extraction were higher than thermal -reflux extraction，and the half -scavenging concentration （IC50）value of DPPH·，ABTS+·，O2-·and·OH for mango kernel polyphenols via ultrasonicassisted extraction were 0.02，0.24，592.98，38.76 mg/mL，respectively.Furthermore，ultrasonic -assisted extraction was characterized by time saving and low cost.