Abstract:The sturgeon cartilage and the chicken cartilage are by-products in the processing of fish and poultry，which are rich in various bioactive substances such as chondroitin sulfate and hyaluronic acid.The sturgeon and chicken cartilage were used as raw materials，some excipients were added and wet granule pressing technique was used to prepare chewing tablets.Through single factor test and orthogonal test，the optimum formulation of the tablet was optimized，and the optimum technology and formulation were explored.New types of sturgeon and chicken cartilage powder chewable tablets were developed and their qualities were evaluated.The optimum formulation of sturgeon cartilage powder chewable tablets was determined by experiments：9.4 g fish cartilage powder，adding 3.5 mL 65%ethanol wetting agent，10 g maltodextrin，0.4 g microcrystalline cellulose，5.6 g lactose powder as filler，with 2 % magnesium stearate as a lubricant.The optimum formula for chicken cartilage powder chewable tablets was：9.4 g chicken cartilage powder，adding 8 mL 45%ethanol wetting agent，10 g maltodextrin，0.6 g microcrystalline cellulose，6.1 g lactose powder as filler，with 2%magnesium stearate as a lubricant.The products with a good taste and good flavor were prepared.