Abstract:Quinoa bran was used as main raw material to extract quinoa bran saponin by supercritical CO2 extraction，and the extraction process was optimized by response surface methodology.The results showed that the optimal process parameters were supercritical pressure 37 MPa，supercritical temperature 60 ℃，extraction time 96 min and ethanol concentration 74%.Under these conditions，the extraction rate of quinoa bran quinoa bran saponin was 0.96 %.Factors influencing the extraction rate of quinoa bran branded saponins were as follows：supercritical pressure ＞ extraction time ＞ supercritical temperature ＞ ethanol concentration.The extraction of quinoa bran saponin by supercritical technology can be used for reference to improve the added value of quinoa bran，and provide technical reference for quinoa bran further development of new products.