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投稿时间：2018-12-31
投稿时间：2018-12-31
中文摘要: 观察山药多糖对急性酒精中毒小鼠的解酒作用。分别给小鼠灌食不同剂量的山药多糖，30 min 后灌胃56°白酒（按40 mL/kg 体重），灌胃结束后测定行为学指标（醉酒耐受时间、醉酒持续时间），进一步分析血液中乙醇、乙醛质量浓度，检测肝组织中乙醇脱氢酶（alcohol dehydrogenase，ADH）、超氧化物歧化酶（superoxide dismutase，SOD）活性、以及血清中谷丙转氨酶（alanine transaminase，ALT）、谷草转氨酶（glutamic oxalacetic transaminase，AST）活性，以探讨山药多糖对急性酒精中毒小鼠的解酒作用。与模型对照组相比，山药多糖能显著延长醉酒耐受时间，缩短睡眠时间，降低乙醇和乙醛质量浓度，一定程度上增加肝组织中ADH、SOD 活性和降低血清中ALT、AST 活性。山药多糖对小鼠醉酒有较好的解酒护肝作用，其作用主要是通过减轻酒精导致的肝细胞损伤来实现。
Abstract:To observe the anti-alcoholism effects of rhizoma dioscoreae polysaccharide on acute alcoholism mice.The mice were gavaged with the low，medium and high doses of rhizoma dioscoreae polysaccharide，respectively.After 30 min，56°Chinese liquor at a dose of 40 mL/kg was used to establish a mouse model of acute Alcoholism.The behavioral studies of drunked latency and the sleeping time of drunk mice were assayed.alcohol dehydrogenase（ADH）and the superoxide dismutase （SOD）activity in liver and the alanine transaminase（ALT）and the aspertate aminotransferase （AST）in blood serum were assayed．The results showed that rhizoma dioscoreae polysaccharide significantly reduced toletance time and decreased the drunken time of mice in mice with acute alcoholism upon rhizoma dioscoreae polysaccharide administration.In addition，ADH and SOD activity were significantly increased，the activity of ALT and AST in serum were significantly reduced.Rhizoma dioscoreae polysaccharide had certain anti-alcoholism effects on alcohol-poisioned mice，and its role was realized by alleviating liver damage on alcohol-induced liver injury.
文章编号：201919020 中图分类号： 文献标志码：
基金项目:国家自然科学基金（30901877）；河南省科技厅科技攻关项目（1152102210125）；河南省教育厅自然科学重点科技攻关项目（14A180008）
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