Abstract:Biosensor，as a tool for rapid detection of biomolecules，has shown its great potential of application in detection and diagnosis of pathogenic bacteria in food，crops，clinical medicine，and other fields.And visual optical biosensor has attracted much attention because of its advantages of quickness，sensitivity，accuracy and high selectivity.This paper mainly summarized the latest research progresses from three aspects of colorimetric optical biosensor，plasma optical biosensor and microfluid optical biosensor，discussed characteristics，application fields and main problems of various optical biosensors，and expounded the application prospects of diversified integrated optical biosensors in the field of detection and supervision on food safety in the future.