Abstract:The inhibitory effects of areca nut extracts on α -glucosidase were studied，and the dynamic properties were analyzed by lineweaver-burk double reciprocal method.Results indicated that the areca husk，seed and flower extracts were all had certain inhibitory effect on α-glycosidase，IC50were（2.87 ±0.48）mg/mL，（1.50±0.31）μg/mL and（4.00 ±0.53）mg/mL，respectively.Inhibitory effect of areca seed extract was obviously higher than that of positive control acarbose [IC50was （0.71±0.09）mg/mL].By analyzing the polyphenols and polysaccharides in the extracts，it was found that the content of polyphenols and polysaccharides in the areca seed extract was higher，which was （441.73±4.79）mg/g and （411.47±6.01）mg/g，respectively.The kineticresults showed that the inhibitory effect of areca husk and areca seed extracts on α-glucosidase was a mixture of competitive inhibition and non-competitive inhibition.While the inhibitory effect of areca flower extract on αglucosidase was a mixture of competitive and anti-competitive inhibition.The results indicated that the extracts of areca nut had significant inhibitory effect on α-glucosidase，which had good value of development and utilization.