Abstract:The anti-diabetes effects of the chickpea ethanol extracts was studied.Streptozocin-induced diabetic mice were intragastricly administrated with different doses of chickpea ethanol extracts [low dose 200 mg/（kg·d·BW），middle dose 400 mg/（kg·d·BW），high dose 800 mg/（kg·d·BW）]and positive group[melbine：227.5 mg/（kg·d·BW）].Four weeks later，diabetic mice's serum glucose level，insulin level，antioxidative enzymes activities were determined and pathological changes of liver and pancreas were observed by hematoxylin and eosin （HE）staining.The serum glucose levels of chickpea ethanol extract groups at low，middle，and high dose were only 83.4%，60.0%，and 67.9%of those in the model group，respectively （P＜0.05） and the middle dose group had the most significant hypoglycemic effects.The serum insulin levels，insulin resistance index，and insulin sensitivity index of middle dose group were only 39.74%，31.09%，and 1.22 times of those in the model group（P＜0.05）；and no significant differences of the above three indexes were found between middle dose group and the positive group （P ＞0.05）.Moreover，in the middle dose group，activities of total-superoxide dismutase（T-SOD），glutathione peroxidase（GSH-Px），catalase（CAT），and malondialdehyde （MDA）content were 1.09 times，1.03 times，1.36 times，and 76.4% of those in the model group（P＜0.05）；and the morphology and structure of liver cells and islet cells tended to be normal.