Abstract:High-fat model mice were given intragastric administration with different doses of tamping ultrafine powder to study the effect of ultra-fine powder on the four indicators of serum lipids and related enzymes in serum and liver tissue.The results showed that compared with the high-fat model group，the body weight of mice fed the ultra-fine powder group was significantly reduced，liver index and atherosclerosis index were also significantly reduced；serum total cholesterol（TC），triglyceride（TG），and low density lipoprotein cholesterol（LDL-C）levels in mice Significantly lower，high density lipoprotein cholesterol （HDL-C）levels were significantly higher；the total superoxide dismutase（T-SOD）and hepatic lipase（HL）activity in the low-，medium-，and high-dose groups of mice fed ultra-fine powder was higher than that in the high-fat model group，and the malondialdehyde（MDA）content was increased.Lower than the high fat model group.It can be seen that the ultrafine powder can reduce blood lipid levels in hyperlipidemia mice and improve the degree of hepatic fat accumulation and atherosclerosis caused by excessive lipid intake and it also has protective effect on lipid peroxidation injury caused by hyperlipidemia.