Abstract:The role and mechanism of health foods with Apocynum venetum，hawthorn and cassia as main components in assisting lipid-lowering was explored.Apocynum venetum，hawthom and cassia seed extracts were optimized to prepare Apocynum venetum lipid-lowering capsules.According to the evaluation method of health food，the rat mixed hyperlipidemia model was duplicated to observe the changes in body weight，liver weight and serum lipids of rats with hyperlipidemia at 30 and 45 days.Besides，Cysteine-containing aspartate proteolytic enzymes（Caspase），including Caspase-9，Caspase-3，and Cleave Caspase-3 protein expression，were detected by the method of Western blot.The results showed that after the process optimization，the concentrated paste was concentrated to a weight of 49 g，12.6 g of dextrin was added，and the weight was 43.8 g after drying and pulverization，and the water content was 3.04 %，and the Apocynum venetum lipid-lowering capsule was prepared.Capsules could improve the body weight，liver weight coefficient，blood lipid index and tissue morphology abnormalities induced by hyperlipidemia.At the same time，Apocynum venetum lipidlowering capsule might play a role in improving mixed hyperlipidemia by regulating the expression level of Caspase family proteins.