Abstract:The effects of Schisandra lignans on the negative emotion and behavior of rats with sleep deprivation were investigated.The experimental rats were randomly divided into three groups：large platform control group，small platform deprivation group and Schisandra lignan group.After three days of deprivation of the water platform sleep deprivation device，the animals were subjected to elevated cross maze test，forced swimming test，weight-bearing swimming test and record indicators.Compared to large platform control group，small platform deprivation group had significantly decreased the proportion of time and number of rats entering the open arms，prolonged the time of forced swimming and reduced the duration time from swimming to exhaustion.Compared with small platform deprivation,Schisandra lignans group had significantly increased the proportion of time and number of opening arms，attenuated the time of forced swimming and prolonged the swimming to exhaustion time.Schisandra lignans had the protective effects on anxiety，depression and fatigue caused by sleep deprivation.