Abstract:The number of deaths due to high blood pressure has been increasing year by year，and patients with hypertension are becoming more and more younger since 1960.Moreover，high blood pressure could cause many high-risk diseases.It is difficult to cure and is becoming a major threat to human health.The species of marine macroalgae are abundant and have high blood pressure-lowering activity.This article reviewed the types of marine macroalgae，the mechanisms and measuring methods for blood pressure-lowering activity.It also summarized the research status of large seaweed in lowering blood pressure and made a prospect.This might provide a foundation for the development of marine-derived antihypertensive drugs and health products.