Abstract:A high-yield method for the extraction of flavonoids from wild Actinidia arguta in Changbai Mountain as developed by using an integrated ultrasonic and microwave reaction system.On the basis of single-factor experiments，the response surface methodology was used to optimize the extraction process.The results indicated that the optimum conditions for extraction were as follows：liquid/material ratio 25 ∶1（mL/g）；ultrasonic power 350 W；ultrasonic time 7 min；microwave power 360 W；microwave time 336 s.In this process conditions，the extraction yield of flavonoids could reach about（7.33±0.002）%.