Abstract:Lycium ruthenicum Murr.dried fruit was used to prepare instant powder.The extraction process was optimized through orthogonal test.Four kinds of way to dry Lycium ruthenicum Murr.aqueous extract（hot air drying，ultrasonic drying，freeze drying and spray drying）were compared.Spray drying process was optimized by using response surface method.In addition，the micro morphology，particle size，and dissolution time of the obtained instant powder were studied.Ultrasonic extraction results showed that the optimal extraction conditions were as follows：ultrasonic power 400 W，solid-to-solvent ratio 1∶20（g/mL），extraction temperature 20℃，extraction time 50 min.The optimal spray drying technological parameters were 190℃，20 mL/min and 1.01 g/mL for inlet air temperature，inject speed and liquor density，respectively.The particle size of Lycium ruthenicum Murr.powder produced by spray drying was uniform.According to the analysis results of the laser particle size analyzer，the range of size distribution was 4 μm-60 μm and the mean particle size was 17 μm.The average dissolution time of instant powder was 43.4 s，which reached the industry standard.