Abstract:Abstract：To evaluate the toxicity of ginseng ophiopogon liquor from the perspective of acute toxicity and hereditary toxicity.Using ultra-high pressure extraction of ginseng and other medicinal materials，prepared into a ginseng wine with anti-fatigue effect.The acute toxicity test in mice was performed using the maximum tolerated dose method.Ames test，mouse bone marrow cell micronucleus test，and mouse sperm abnormality experiment were used to observe genetic toxicity.The acute toxicity dose was 20 000 mg/kg bw.Animals in each group had normal diet and activities，and they grew well.No signs of poisoning and death were seen.Ames test was negative at 5 000，1 000，200，40，8 μg/dish.The results of the mouse bone marrow cell micronucleus test and mouse sperm abnormality test in the 2，4 and 8 mL/kg bw dose groups were all negative.Ginseng ophiopogon liquor is non-toxic and cannot cause genetic mutation in mice.