Abstract:Abstract：In order to study the antioxidant function and optimum dosage of the solution of microcapsule loading anthocyanidins from Lycium ruthenicum Murr by modified β-glucan from highland barley.The anthocyanin of Lycium ruthenicum Murr was used as raw material coated with highland barley β-glucan to form a microcapsule.Taking SPF BALB/c mice as experimental receptor，animals were divided into five groups including 1 times，4 times，8 times and blank control group and ascorbic acid positive control group.After 7 days pre-experiment and condition adaptation，the mice in each group were given intragastric administration of 0.2 mL/d for four weeks.The activity of antioxidant enzymes and the content of lipid peroxide （LPO）were measured，and the results were statistically analyzed.Results have been get as follows.Compared with blank control group，the solution of microcapsule loading anthocyanidins from Lycium ruthenicum Murr by modified β-glucan from highland barley in each dose group could improve the activity of superoxide dismutase（SOD）and glutathione peroxidase（GSH-PX）in serum and tissues of mice and reduce the content of lipid peroxide and lipofuscin in the tissue.Through analysis，it found that high dose group（8 mg/mL）was the best dose group.