Abstract:This paper studied the extraction process of polyphenols in noni by microwave，and tested its oxidation resistance.According to single factor experimental result，the microwave extraction process was optimized using response surface analysis.The optimal extraction conditions were determined as follows：the concentration of ethanol was 40%，liquid-solid ratio was 30∶1 （mL/g），reaction time was 4 min，microwave power was 300 W the content of polyphenol was 2.45 mg/g.The extract found that the removal rate of DPPH radical was 58.62%and the removal rate of ABTS+radical was 51.46%，the removal effect was obvious，which proves that it has good antioxidant capacity.