Abstract:This experiment studied the intervention effect of a fermented beverage enriched D-pinitol on liver damage of STZ-induced type 2 diabetic rat.To develop a fermented beverage which was low sugar，the fermentation of Saccharomyces cerevisiae and lactic acid bacteria with the carob powder extract enriched D-pinitol was been stuied.The type 2 diabetic rat were fed enrich-food for 4 weeks before administrated STZ，the SD rats were divided into normal control group，model control group，positive control group，low dose of fermented beverage enriched D-pinitol，high dose of fermented beverage enriched D-pinitol.After 4 weeks of a daily dose of the fermented beverage enriched D-pinitol，some biochemical parameters were measured，which includes FBG，the liver index，ALT，AST test and the pathology morphology change of rat liver tissue cell under research microscope.The Results showed that：Compared with normal control group，the serum AST，ALT level increased extremely significantly（P＜0.01），HE staining showed hepatocyte steatosis significantly in model control group rat，liver tissue structure was not clear，the arrangement of liver cell was disordered.Compared with model control group，the serum AST，ALT level decreased significantly（P＜0.05），HE staining showed liver steatosis decreased significantly in positive control group and dose group，the arrangement of liver cell was well-regulated.The fermented beverage enriched D-pinitol has the positive intervention effect on liver damage of type 2 diabetic rat.