Abstract:Ultrasonic-microwave synergistic extraction of polysaccharides from Cyclocarya paliurus was proposed.The optimal conditions of extraction time，solvent-to-solid ratio，ultrasonic power and microwave power for extracting polysaccharides from Cyclocarya paliurus were studied，respectively.The combined use of ultrasonic and microwave provided a time-saving and high-yield method for polysaccharides extraction from Cyclocarya paliurus.The optimal conditions of extraction was ultrasonic power 360 W，microwave power 100 W and the treatment time 20 min，the yield extraction of polysaccharides was 10.02%.The antioxidant，antitumor activity and hypoglycemic activity of the polysaccharide from Cyclocarya paliurus were studied，the polysaccharides had very strong antioxidant ability，low antitumor activity and high hypoglycemic activity.The polysaccharide extracted by ultrasonic microwave method exhibited higher activity.The results showed the method was not only efficient，but also can improve the activity of polysaccharides.