Abstract:To study the impact of Quanxie health-care wine on immunity function in mice.A total of 200 SPF ICR male mice were randomly divided into 5 batches，each of which consisted of negative control group，vehicle control group and high，medium and low dosage （0.85，1.7，5.1 g/kg·bw）of Quanxie health-care wine group.The negative control group was given purified water，the vehicle control group was given 15%wine base，and each mouse was orally administered once a day，for 30 days.The immune indexes including ConA-induced lymphocyte transformation ability，delayed type hypersensitivity，serum hemolysin level，antibody producing cell count，carbon clearance ability，macrophage phagocytosis of chicken erythrocytes capacity and NK cell activity were detected.Compared with the vehicle control group，high dosage of Quanxie health-care wine group could significantly strengthen the ConA-induced lymphocyte transformation ability of mice （P＜0.05），enhance the delayed type hypersensitivity of mice（P＜0.05）and increase the level of antibody producing cell（P＜ 0.05）；the medium and low dosage of Quanxie health-care wine group could significantly strengthen NK cell activity.However，Quanxie health-care wine had no significant effects on ratio of spleen weight to body weight，ratio of thymus weight to body weight，serum hemolysin level，carbon clearance ability and macrophage phagocytosis of chicken erythrocytes capacity（P＞0.05）.Quanxie health-care wine can enhance immunity function in mice.