Abstract:The aim of this study was to investigate the effects of Momordica charantia L. polysaccharide（BGPs） on fatigue and oxidative damage in exercise-exhaustive mice. The animals were treated with BGPs prepared by alcohol submerged extraction method for 21 days by gavage. The exhaustive swimming time， lactate， lactate de－ hydrogenase and urea nitrogen in serum， glycogen in liver and muscle， the activities of glutathione peroxidase （GPX）and superoxide dismutase （SOD） as well as the content of malondialdehyde （MDA） in liver and heart were measured. Compared with the exercise-exhaustive mice， BGPs prolonged the weight-bearing swimming time， increased the glycogen levels of liver and muscle， reduced the accumulation of blood lactic acid and urea nitrogen， and improved the activity of lactate dehydrogenase. In addition， the improved activities of antioxidases （SOD and GPX）and the reduced MDA levels in heart and liver of BGPs treated mice were observed. The results showed that BGPs had significant protective effects against exercise-fatigue，relieved oxidative damage caused by free radicals after high intensity exercise， and promoted the recovery of body function.