Abstract:To study toxicological security of lycopene microcapsule.Acute toxicity test， genetic toxicity test （Ames test， micronucleus test of born marrow， mice testicle cells chromosome aberration test） and thirty-day feeding test in rats were conducted in this study. Result： the oral MTD in both male and female mice were more than 15 000 mg/kg·bw， and it is non-toxic， the results of Ames test， micronucleus test of born marrow in mice， mice testicle cells chromosome aberration test were negative， the results of the thirty-day feeding test in rats demonstrated that it had no obvious toxic effects on growth and development， routine blood index， biochemical index and histopathological changes. Lycopene microcapsule has no significant acute and mutagenic effect and sub-acute toxicity， it is safe as a health food.