Abstract:The technique of direct powder compression and orthogonal design were employed to optimize the formulation of yam powder chewable tablet， and the stability was also investigated. The results shown that the optimal formulation of yam powder chewable tablet was as follows： yam powder ∶ microcrystalline ∶ magnesium stearate ∶ mogroside= 250 ∶ 750 ∶ 1 ∶ 5， and the hardness and breakage were met the demand. In addition， be－ cause humidity had distinct influence on stability of the chewable tablet， while temperature and light had no in－ fluence， it is important to keep away from moisture and water in the process of producing， packaging， storage and transportation.