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投稿时间：2016-12-13
投稿时间：2016-12-13
中文摘要: 研究苦瓜水溶性膳食纤维（Water-soluble dietary fiber，SDF）的降血糖功效。试验腹腔注射四氧嘧啶制备糖尿病 小鼠模型，设置 SDF 3 个剂量组、模型对照组和阳性药物对照组，通过测定小鼠空腹血糖和糖耐量研究 SDF 的降血糖效 果，通过测定总抗氧化能力（Total Antioxidant Capacity，T-AOC）、过氧化物歧化酶（Superoxide Dismutase，SOD）、谷胱甘 肽过氧化物酶（Glutathione Peroxidase，GSH-PX）活性和丙二醛（Malonaldehyde，MDA）、肿瘤坏死因子-α（Tumor Necrosis Factor-α，TNF-α）和白细胞介素-6 （Interleukin-6，IL-6）水平研究 SDF 的降血糖机制。SDF 能降低糖尿病小鼠血糖水 平，提高糖尿病模型小鼠的葡萄糖耐量，降低机体氧化应激水平和炎性水平。SDF 可以改善糖尿病小鼠血糖水平可能与 其抗氧化和抗炎活性有关。
Abstract:A mouse model of diabetes induced by intraperitoneal injection of alloxan was established to investi－ gate the hypoglycemic effect of Water soluble dietary fiber （SDF）. Mice were randomly divided into 3 groups： high-，medium-and low-dose SDF-treated groups， glibenclamide-treated group and model control group，the levels of blood glucose and glucose tolerance were dedected to evaluation the hypoglycemic effect of SDF， the levels of T-AOC，SOD，GSH-PX，MDA，TNF-α and IL-6 glucose tolerance were dedected to reaserch the hy－ poglycemic mechanism of SDF.SDF showed excellent hypoglycemic and glucose tolerance improveabilities. The levels of T-AOC，SOD，GSH-PX were obviously inecreased and MDA，TNF-α and IL-6 were obviously de－ creased in diabetes rats after SDF was intaked.These results showed that the hypoglycemic activity of SDF maybe realated with anti-oxidative and anti-inflammation.
keywords: Momordica charantia L. water-soluble dietary fiber blood sugar anti-oxidation anti-inflammatory
文章编号：201710005 中图分类号： 文献标志码：A
基金项目:河北省农林科学院青年基金项目 （A2015050101）；河 北省科技计划项目（17227101D）；河北省科学技术研究与发展计划 项目（11231005D）；河北省中药材产业体系项目（11232025D）；河北 省农林科学院财政项目（F17R02-01）
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