Abstract:A simple and rapid method for determination of six alkylamines in food contact plastic package materials by ultra-high performance liquid chromatography tandem mass spectrometry （UPLC-MS/MS）coupled with dispersive solid phase extraction（d-SPE）was established.The plastic sample was extracted with acetone under ultrasonication，and purified by a simple d-SPE employing PSA and C18 powder.Then the extract was separated on Eclipse Plus C18 UPLC column with acetonitrile and 0.1%formic acid solution （volumn ratio）as mobile phase under gradient elution mode，then detected by tandem mass spectrometry under ESI at positive and multiple reaction monitoring（MRM）mode.The result indicated that the target analytes were in the range of 0.50 μg/L-100 μg/L with correlation coefficient（r）ranging from 0.995 8 to 0.999 3，the method detection limit（LOD，S/N＝3）of the analytes were ranged from 0.23 μg/kg-0.56 μg/kg.The mean recoveries were in the range of 83.6%to 103%，with the precision ranging from 2.3%to 6.1%（n＝6）.