Abstract:L-Carnitine plays an intermediary role in the fatty oxidational catabolism. At present， research is manly on the evaluation of carnitine functions and its effect on exercise performance， but few studies focus on L-carnitine synergists for promoting the fatty catabolism. Through collecting and arranging the chinese and for－ eign theses， this paper described how synergists cause the synergy for carnitine and offer future prospects by classifying the synergists and summarizing their mechanism for promoting the fatty catabolism. It was found that synergists can be classified into 7 groups： alkaloids， polyphenols， phytochemicals， minerals， vitamins， fatty acids and the others. It provided insights into the future research of treating obesity by combining L-carnitine with its synergists . Developing new synergists will be more pertinent and it will also benefits for designing func－ tional drink whose formula contain L-carnitine.