Abstract:To study the immunomodulatory effect of polysaccharide from Glycyrrhiza inflata Bat. in the immune function of mice， immunosuppressed mouse models were established by feeding cyclophosphamied（CTX），with physiological saline as blank control group. To the model mice were fed low， medium and high dose of polysac－ charide solution， 7 days in a row， feeding the polysaccharide solution mass fraction was respectively 80， 160， 320 mg/kg. By calculating the thymus index and spleen index， the test of macrophage cell in abdominal cavity activity and serum hemolysin experiment， such as immune activity of expanding fruit licorice polysaccharide were studied. The three immune indexes showed that swelling fruit of Glycyrrhiza polysaccharide on mice specif－ ic immune and nonspecific immune positive regulatory role， and had a dose effect relationship.